compound c Search Results


3 chloro 7 hydroxy 4 methylcoumarin chlorferon  (LGC Standards)
93
LGC Standards 3 chloro 7 hydroxy 4 methylcoumarin chlorferon
3 Chloro 7 Hydroxy 4 Methylcoumarin Chlorferon, supplied by LGC Standards, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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compound c  (MedChemExpress)
96
MedChemExpress compound c
FIGURE 5 | AMPK/FOXO3A signaling was required for solasonine-induced cell cycle arrest and apoptosis in acute monocytic leukemic cell lines. (A) Immunoblotting analysis showed that inhibition of AMPK activity by <t>compound</t> <t>C</t> prevented the solasonine-induced nuclear translocation of FOXO3A. (B, C) Bar chart showed that compound C decreased the solasonine induced apoptosis (B) and restored the cell cycle arrest in the G2/M phase (C) in THP-1 and MV4-11cells through Flow cytometry analysis. (D) Immunoblotting analysis showed that compound C decreased the solasonine-induced apoptosis related protein in THP-1 and MV4-11cells. (CON represented cells not treated solasonine and compound C; *P < 0.05).
Compound C, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bml‑275  (TargetMol)
99
TargetMol bml‑275
FIGURE 5 | AMPK/FOXO3A signaling was required for solasonine-induced cell cycle arrest and apoptosis in acute monocytic leukemic cell lines. (A) Immunoblotting analysis showed that inhibition of AMPK activity by <t>compound</t> <t>C</t> prevented the solasonine-induced nuclear translocation of FOXO3A. (B, C) Bar chart showed that compound C decreased the solasonine induced apoptosis (B) and restored the cell cycle arrest in the G2/M phase (C) in THP-1 and MV4-11cells through Flow cytometry analysis. (D) Immunoblotting analysis showed that compound C decreased the solasonine-induced apoptosis related protein in THP-1 and MV4-11cells. (CON represented cells not treated solasonine and compound C; *P < 0.05).
Bml‑275, supplied by TargetMol, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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epi testosterone  (Cerilliant Corporation)
88
Cerilliant Corporation epi testosterone
FIGURE 5 | AMPK/FOXO3A signaling was required for solasonine-induced cell cycle arrest and apoptosis in acute monocytic leukemic cell lines. (A) Immunoblotting analysis showed that inhibition of AMPK activity by <t>compound</t> <t>C</t> prevented the solasonine-induced nuclear translocation of FOXO3A. (B, C) Bar chart showed that compound C decreased the solasonine induced apoptosis (B) and restored the cell cycle arrest in the G2/M phase (C) in THP-1 and MV4-11cells through Flow cytometry analysis. (D) Immunoblotting analysis showed that compound C decreased the solasonine-induced apoptosis related protein in THP-1 and MV4-11cells. (CON represented cells not treated solasonine and compound C; *P < 0.05).
Epi Testosterone, supplied by Cerilliant Corporation, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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compound c s7306  (Selleck Chemicals)
95
Selleck Chemicals compound c s7306
FIGURE 5 | AMPK/FOXO3A signaling was required for solasonine-induced cell cycle arrest and apoptosis in acute monocytic leukemic cell lines. (A) Immunoblotting analysis showed that inhibition of AMPK activity by <t>compound</t> <t>C</t> prevented the solasonine-induced nuclear translocation of FOXO3A. (B, C) Bar chart showed that compound C decreased the solasonine induced apoptosis (B) and restored the cell cycle arrest in the G2/M phase (C) in THP-1 and MV4-11cells through Flow cytometry analysis. (D) Immunoblotting analysis showed that compound C decreased the solasonine-induced apoptosis related protein in THP-1 and MV4-11cells. (CON represented cells not treated solasonine and compound C; *P < 0.05).
Compound C S7306, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cotinine d 3  (Millipore)
91
Millipore cotinine d 3
FIGURE 5 | AMPK/FOXO3A signaling was required for solasonine-induced cell cycle arrest and apoptosis in acute monocytic leukemic cell lines. (A) Immunoblotting analysis showed that inhibition of AMPK activity by <t>compound</t> <t>C</t> prevented the solasonine-induced nuclear translocation of FOXO3A. (B, C) Bar chart showed that compound C decreased the solasonine induced apoptosis (B) and restored the cell cycle arrest in the G2/M phase (C) in THP-1 and MV4-11cells through Flow cytometry analysis. (D) Immunoblotting analysis showed that compound C decreased the solasonine-induced apoptosis related protein in THP-1 and MV4-11cells. (CON represented cells not treated solasonine and compound C; *P < 0.05).
Cotinine D 3, supplied by Millipore, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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2 3 7 8 tetrachlorodibenzo p dioxin tcdd  (Cerilliant Corporation)
91
Cerilliant Corporation 2 3 7 8 tetrachlorodibenzo p dioxin tcdd
FIGURE 5 | AMPK/FOXO3A signaling was required for solasonine-induced cell cycle arrest and apoptosis in acute monocytic leukemic cell lines. (A) Immunoblotting analysis showed that inhibition of AMPK activity by <t>compound</t> <t>C</t> prevented the solasonine-induced nuclear translocation of FOXO3A. (B, C) Bar chart showed that compound C decreased the solasonine induced apoptosis (B) and restored the cell cycle arrest in the G2/M phase (C) in THP-1 and MV4-11cells through Flow cytometry analysis. (D) Immunoblotting analysis showed that compound C decreased the solasonine-induced apoptosis related protein in THP-1 and MV4-11cells. (CON represented cells not treated solasonine and compound C; *P < 0.05).
2 3 7 8 Tetrachlorodibenzo P Dioxin Tcdd, supplied by Cerilliant Corporation, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dorsomorphin dihydrochloride  (TargetMol)
99
TargetMol dorsomorphin dihydrochloride
FIGURE 5 | AMPK/FOXO3A signaling was required for solasonine-induced cell cycle arrest and apoptosis in acute monocytic leukemic cell lines. (A) Immunoblotting analysis showed that inhibition of AMPK activity by <t>compound</t> <t>C</t> prevented the solasonine-induced nuclear translocation of FOXO3A. (B, C) Bar chart showed that compound C decreased the solasonine induced apoptosis (B) and restored the cell cycle arrest in the G2/M phase (C) in THP-1 and MV4-11cells through Flow cytometry analysis. (D) Immunoblotting analysis showed that compound C decreased the solasonine-induced apoptosis related protein in THP-1 and MV4-11cells. (CON represented cells not treated solasonine and compound C; *P < 0.05).
Dorsomorphin Dihydrochloride, supplied by TargetMol, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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uracil 5 monophosphate trisodium chem impex  (Chem Impex International)
95
Chem Impex International uracil 5 monophosphate trisodium chem impex
FIGURE 5 | AMPK/FOXO3A signaling was required for solasonine-induced cell cycle arrest and apoptosis in acute monocytic leukemic cell lines. (A) Immunoblotting analysis showed that inhibition of AMPK activity by <t>compound</t> <t>C</t> prevented the solasonine-induced nuclear translocation of FOXO3A. (B, C) Bar chart showed that compound C decreased the solasonine induced apoptosis (B) and restored the cell cycle arrest in the G2/M phase (C) in THP-1 and MV4-11cells through Flow cytometry analysis. (D) Immunoblotting analysis showed that compound C decreased the solasonine-induced apoptosis related protein in THP-1 and MV4-11cells. (CON represented cells not treated solasonine and compound C; *P < 0.05).
Uracil 5 Monophosphate Trisodium Chem Impex, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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amino acid  (Chem Impex International)
95
Chem Impex International amino acid
FIGURE 5 | AMPK/FOXO3A signaling was required for solasonine-induced cell cycle arrest and apoptosis in acute monocytic leukemic cell lines. (A) Immunoblotting analysis showed that inhibition of AMPK activity by <t>compound</t> <t>C</t> prevented the solasonine-induced nuclear translocation of FOXO3A. (B, C) Bar chart showed that compound C decreased the solasonine induced apoptosis (B) and restored the cell cycle arrest in the G2/M phase (C) in THP-1 and MV4-11cells through Flow cytometry analysis. (D) Immunoblotting analysis showed that compound C decreased the solasonine-induced apoptosis related protein in THP-1 and MV4-11cells. (CON represented cells not treated solasonine and compound C; *P < 0.05).
Amino Acid, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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compound c  (LGC Standards)
86
LGC Standards compound c
FIGURE 5 | AMPK/FOXO3A signaling was required for solasonine-induced cell cycle arrest and apoptosis in acute monocytic leukemic cell lines. (A) Immunoblotting analysis showed that inhibition of AMPK activity by <t>compound</t> <t>C</t> prevented the solasonine-induced nuclear translocation of FOXO3A. (B, C) Bar chart showed that compound C decreased the solasonine induced apoptosis (B) and restored the cell cycle arrest in the G2/M phase (C) in THP-1 and MV4-11cells through Flow cytometry analysis. (D) Immunoblotting analysis showed that compound C decreased the solasonine-induced apoptosis related protein in THP-1 and MV4-11cells. (CON represented cells not treated solasonine and compound C; *P < 0.05).
Compound C, supplied by LGC Standards, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


FIGURE 5 | AMPK/FOXO3A signaling was required for solasonine-induced cell cycle arrest and apoptosis in acute monocytic leukemic cell lines. (A) Immunoblotting analysis showed that inhibition of AMPK activity by compound C prevented the solasonine-induced nuclear translocation of FOXO3A. (B, C) Bar chart showed that compound C decreased the solasonine induced apoptosis (B) and restored the cell cycle arrest in the G2/M phase (C) in THP-1 and MV4-11cells through Flow cytometry analysis. (D) Immunoblotting analysis showed that compound C decreased the solasonine-induced apoptosis related protein in THP-1 and MV4-11cells. (CON represented cells not treated solasonine and compound C; *P < 0.05).

Journal: Frontiers in oncology

Article Title: Solasonine Suppresses the Proliferation of Acute Monocytic Leukemia Through the Activation of the AMPK/FOXO3A Axis.

doi: 10.3389/fonc.2020.614067

Figure Lengend Snippet: FIGURE 5 | AMPK/FOXO3A signaling was required for solasonine-induced cell cycle arrest and apoptosis in acute monocytic leukemic cell lines. (A) Immunoblotting analysis showed that inhibition of AMPK activity by compound C prevented the solasonine-induced nuclear translocation of FOXO3A. (B, C) Bar chart showed that compound C decreased the solasonine induced apoptosis (B) and restored the cell cycle arrest in the G2/M phase (C) in THP-1 and MV4-11cells through Flow cytometry analysis. (D) Immunoblotting analysis showed that compound C decreased the solasonine-induced apoptosis related protein in THP-1 and MV4-11cells. (CON represented cells not treated solasonine and compound C; *P < 0.05).

Article Snippet: THP-1 and MV4-11 cells (1×105/ml) suspended in 6 ml culture media were seeded in a 6-well culture plate and treated with different concentration of solasonine, 2 mM compound C, or 8 mM solasonine+2 mM compound C for 24 h. Cells were lysed with RIPA buffer (Beyotime, China) containing inhibitor cocktail (MedChem Express, USA).

Techniques: Western Blot, Inhibition, Activity Assay, Translocation Assay, Flow Cytometry